MARC ayrıntıları
| 000 -BAŞLIK |
|---|
| Sabit Uzunluktaki Kontrol Alanı |
03683nam a22003137a 4500 |
| 003 - KONTROL NUMARASI KİMLİĞİ |
|---|
| Kontrol Alanı |
KOHA |
| 005 - EN SON İŞLEM TARİHİ ve ZAMANI |
|---|
| Kontrol Alanı |
20230417095221.0 |
| 008 - SABİT UZUNLUKTAKİ VERİ ÖGELERİ - GENEL BİLGİ |
|---|
| Sabit Alan |
230214d2022 cy ||||| m||| 00| 0 eng d |
| 040 ## - KATALOGLAMA KAYNAĞI |
|---|
| Özgün Kataloglama Kurumu |
CY-NiCIU |
| Kataloglama Dili |
eng |
| Çeviri Kurumu |
CY-NiCIU |
| Açıklama Kuralları |
rda |
| 041 ## - DİL KODU |
|---|
| Metin ya da ses kaydının dil kodu |
eng |
| 090 ## - Yerel Tasnif No |
|---|
| tasnif no |
YL 2691 |
| Cutter no |
H67 2022 |
| 100 1# - KİŞİ ADI |
|---|
| Yazar Adı (Kişi adı) |
Hosseini, Rouminasadat |
| 245 14 - ESER ADI BİLDİRİMİ |
|---|
| Başlık |
THE EFFECT OF COMBINATORIAL THERAPEUTICS ON BREAST CANCER CELLS USING NANOPARTICLE DRUG DELIVERY SYSTEM / |
| Sorumluluk Bildirimi |
ROUMINASADAT HOSSEINI; SUPERVISOR: DR. DERAN ERDENGIZ |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
2022 |
| 300 ## - FİZİKSEL TANIMLAMA |
|---|
| Sayfa, Cilt vb. |
55 sheets; |
| Boyutları |
31 cm. |
| Birlikteki Materyal |
Includes CD |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| Content type code |
txt |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| Media type code |
n |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| Carrier type code |
nc |
| 502 ## - TEZ NOTU |
|---|
| Tez Notu |
Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Department |
| 504 ## - BİBLİYOGRAFİ NOTU |
|---|
| Bibliyografi Notu |
Includes bibliography (sheets 47-55) |
| 520 ## - ÖZET NOTU |
|---|
| Özet notu |
ABSTRACT<br/>Breast cancer is one of the most common types of cancer with an estimated incidence <br/>rate of 2.26 million in 2020 and ranked number one as leading cause of cancer <br/>mortality in women. So far it has been treated and controlled by conventional therapies <br/>such as chemotherapy, radiation therapy and surgery. Since 2010, nanoparticle drug <br/>delivery systems have demonstrated great potential in the treatment of cancers. When <br/>compared to conventional therapeutics, the advantages of nanoparticles include lower <br/>side effects, higher biocompatibility, and greater stability, enhanced targeting, and <br/>lower toxicity. So far various types of nanoparticles, such as albumin, iron oxide, gold <br/>and silver nanoparticles have shown great potential in cancer treatment and drug <br/>delivery; furthermore, recent studies have shown that ZnO nanoparticles (NPs) have <br/>cytotoxic effect on cancer cells and can induce apoptosis by generating cellular <br/>oxidative stress. <br/>In addition, researchers are using drug-repurposing methods to further the <br/>development of cancer therapeutics. Experimental data have shown that metformin, <br/>which is originally a type-2 diabetes treatment drug, also has anticancer potentials and <br/>can reduce the proliferation of cancer cells. We hypothesized that combinatorial <br/>exposure of ZnO and metformin-encapsulated carboxymethyl chitosan (MeCMC) NPs <br/>will generate enhanced cytotoxicity and apoptosis, as well as reduced proliferation in <br/>breast cancer cells, compared to single exposure of either one over time. To answer <br/>our hypothesis, we used MDA-MB-231, triple negative breast cancer cell lines, to <br/>assess the differences between combinatorial exposure of ZnO and MeCMC NPs and <br/>their effect alone. The results obtained from the experiment did not show a significant <br/>difference in the cell viability between single and double exposure when comparing <br/>the same concentration of both CMC NP and metformin, however, it showed a <br/>significant decrease of cell viability by comparing the same dose of the drug in <br/>different concentrations of CMC NP between single and double exposure. In addition, <br/>our results indicate that even though combinatorial exposure did not show a significant <br/>change in viability, it may have a significant effect on cell proliferation. <br/>Keywords: Breast cancer, Carboxymethyl Chitosan, Combinatorial Therapeutics, <br/>Drug Delivery, Drug Repurposing, Metformin, Nanoparticle, Zinc Oxide |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ |
|---|
| Konusal terim veya coğrafi ad |
Breast |
| Alt başlık biçimi |
Dissertations, Academic |
| Genel Alt Konu |
Cancer |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ |
|---|
| Konusal terim veya coğrafi ad |
Drug delivery systems |
| Alt başlık biçimi |
Dissertations, Academic |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ |
|---|
| Konusal terim veya coğrafi ad |
Metformin |
| Alt başlık biçimi |
Dissertations, Academic |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ |
|---|
| Konusal terim veya coğrafi ad |
Nanoparticles |
| Alt başlık biçimi |
Dissertations, Academic |
| 700 1# - EK GİRİŞ - KİŞİ ADI |
|---|
| Yazar Adı (Kişi adı) |
Erdengiz, Deran |
| İlişkili Terim |
supervisor |
| 942 ## - EK GİRİŞ ÖGELERİ (KOHA) |
|---|
| Sınıflama Kaynağı |
Dewey Onlu Sınıflama Sistemi |
| Materyal Türü |
Thesis |