SYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON 3-METHYL-1-(4-PHENYL-PIPERAZINE-1-YLMETHYL)-1H-INDOLE / (Kayıt no. 292832)
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| 000 -BAŞLIK | |
|---|---|
| Sabit Uzunluktaki Kontrol Alanı | 02948nam a22002657a 4500 |
| 003 - KONTROL NUMARASI KİMLİĞİ | |
| Kontrol Alanı | KOHA |
| 005 - EN SON İŞLEM TARİHİ ve ZAMANI | |
| Kontrol Alanı | 20241009114232.0 |
| 008 - SABİT UZUNLUKTAKİ VERİ ÖGELERİ - GENEL BİLGİ | |
| Sabit Alan | 240924d2024 cy df||| |||| 00| 0 eng d |
| 040 ## - KATALOGLAMA KAYNAĞI | |
| Özgün Kataloglama Kurumu | CY-NiCIU |
| Kataloglama Dili | eng |
| Çeviri Kurumu | CY-NiCIU |
| Açıklama Kuralları | rda |
| 041 ## - DİL KODU | |
| Metin ya da ses kaydının dil kodu | eng |
| 090 ## - Yerel Tasnif No | |
| tasnif no | YL 3410 |
| Cutter no | O86 2024 |
| 100 1# - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Osoata, Omono Veronica |
| 245 10 - ESER ADI BİLDİRİMİ | |
| Başlık | SYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON 3-METHYL-1-(4-PHENYL-PIPERAZINE-1-YLMETHYL)-1H-INDOLE / |
| Sorumluluk Bildirimi | BY OMONO VERONICA OSOATA ; SUPERVISOR ASST.PROF.DR. BANU KEŞENLI |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024 |
| 300 ## - FİZİKSEL TANIMLAMA | |
| Sayfa, Cilt vb. | 58 sheets : |
| Diğer fiziki detaylar | grafics, illustrations ; |
| Boyutları | 30 cm |
| Birlikteki Materyal | + 1 CD-ROM |
| 336 ## - CONTENT TYPE | |
| Source | rdacontent |
| Content type term | text |
| Content type code | txt |
| 337 ## - MEDIA TYPE | |
| Source | rdamedia |
| Media type term | unmediated |
| Media type code | n |
| 338 ## - CARRIER TYPE | |
| Source | rdacarrier |
| Carrier type term | volume |
| Carrier type code | nc |
| 502 ## - TEZ NOTU | |
| Tez Notu | Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Chemistry |
| 520 ## - ÖZET NOTU | |
| Özet notu | A class of chemical compounds known as indole and its derivatives are one of the<br/>important pharmacophores in the field of medical chemistry. These compounds have<br/>distinct structural characteristics that enable them to engage in a variety of important<br/>biological activities. By varying the location and kind of substituent, indole<br/>derivatives' biological activity can be adjusted. As a result, they have been focus of<br/>in-depth research and use in the field of development and discovery of new drugs.<br/>The flexibility in substitution on indoles provides a powerful tool to explore and<br/>optimize the potential biological effects of these compounds. It opens up possibilities<br/>for designing molecules with enhanced therapeutic properties and targeted<br/>interactions with biological systems. The ability to conveniently modulate the<br/>activities of indole derivatives through structural modifications makes them valuable<br/>candidates for organic synthesis and drug design.<br/>In this work, an indole-piperazine derivative was prepared under reflux condition<br/>through Mannich reaction to yield a 3-methylindole substituted by phenylpiperazine<br/>ring on the N-atom of the indole ring. Proton Nuclear Magnetic Resonance<br/>Spectroscopy (1H-NMR) and Fourier Transform Infra-Red (FT-IR) were used to<br/>characterize the target molecule. The FT-IR spectra of the synthesized molecule,<br/>showed the absence of N-H stretch which indicated that the reaction has actually<br/>taken place at position 1. Also the Mass Spectrometry result (ESI-MS) was used to<br/>confirm the molecular weight of the synthesized molecule and its fragmentation. To<br/>examine the purity of the synthesized molecule, Thin Layer Chromatography (TLC)<br/>and melting point were conducted. Disk diffusion technique was also carried out for<br/>antimicrobial susceptibility studies. The disk diffusion technique showed low to<br/>moderate activity to gram positive (Bacillus) and gram negative ( E. coli)<br/>microorganism. |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ | |
| Konusal terim veya coğrafi ad | Chemistry |
| Alt başlık biçimi | Dissertations, Academic |
| 700 1# - EK GİRİŞ - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Keşanlı, Banu |
| İlişkili Terim | supervisor |
| 942 ## - EK GİRİŞ ÖGELERİ (KOHA) | |
| Sınıflama Kaynağı | Dewey Onlu Sınıflama Sistemi |
| Materyal Türü | Thesis |
| Geri Çekilme Durumu | Kayıp Durumu | Sınıflandırma Kaynağı | Kredi için değil | Koleksiyon Kodu | Kalıcı Konum | Mevcut Konum | Raf Yeri | Kayıt Tarih | Source of acquisition | Toplam Ödünçverme | Yer Numarası | Demirbaş Numarası | Son Görülme Tarihi | Kopya Bilgisi | Fatura Tarihi | Materyal Türü | Genel / Bağış Notu |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Depo | 24.09.2024 | Bağış | YL 3410 O86 2024 | T3827 | 24.09.2024 | C.1 | 24.09.2024 | Thesis | Chemistry | ||||
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Görsel İşitsel | 24.09.2024 | Bağış | YL 3410 O86 2024 | CDT3827 | 24.09.2024 | C.1 | 24.09.2024 | Suppl. CD | Chemistry |