INVESTIGATION OF CHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF EXTRACTS OF SCUTELLARIA SIBTHORPII (BENTH) HALACSY / (Kayıt no. 292893)
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| 000 -BAŞLIK | |
|---|---|
| Sabit Uzunluktaki Kontrol Alanı | 03757nam a22002657a 4500 |
| 003 - KONTROL NUMARASI KİMLİĞİ | |
| Kontrol Alanı | KOHA |
| 005 - EN SON İŞLEM TARİHİ ve ZAMANI | |
| Kontrol Alanı | 20241009121143.0 |
| 008 - SABİT UZUNLUKTAKİ VERİ ÖGELERİ - GENEL BİLGİ | |
| Sabit Alan | 240927d2024 cy e|||| |||| 00| 0 eng d |
| 040 ## - KATALOGLAMA KAYNAĞI | |
| Özgün Kataloglama Kurumu | CY-NiCIU |
| Kataloglama Dili | eng |
| Çeviri Kurumu | CY-NiCIU |
| Açıklama Kuralları | rda |
| 041 ## - DİL KODU | |
| Metin ya da ses kaydının dil kodu | eng |
| 090 ## - Yerel Tasnif No | |
| tasnif no | D 433 |
| Cutter no | K67 2024 |
| 100 1# - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Korkmazer, Çağın |
| 245 10 - ESER ADI BİLDİRİMİ | |
| Başlık | INVESTIGATION OF CHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF EXTRACTS OF SCUTELLARIA SIBTHORPII (BENTH) HALACSY / |
| Sorumluluk Bildirimi | ÇAĞIN KORKMAZER ; SUPERVISOR, ASST. PROF. DR. EMMANUEL MSHELIA HALILU |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024 |
| 300 ## - FİZİKSEL TANIMLAMA | |
| Sayfa, Cilt vb. | 114 sheets ; |
| Boyutları | 30 cm |
| Birlikteki Materyal | +1 CD ROM |
| 336 ## - CONTENT TYPE | |
| Source | rdacontent |
| Content type term | text |
| Content type code | txt |
| 337 ## - MEDIA TYPE | |
| Source | rdamedia |
| Media type term | unmediated |
| Media type code | n |
| 338 ## - CARRIER TYPE | |
| Source | rdacarrier |
| Carrier type term | volume |
| Carrier type code | nc |
| 502 ## - TEZ NOTU | |
| Tez Notu | Thesis (PhD) - Cyprus International University. Institute of Graduate Studies and Research Pharmaceutıcal Sciences |
| 520 ## - ÖZET NOTU | |
| Özet notu | Scutellaria sibthorpii is an endemic plant of Cyprus and it is used in the treatment of<br/>microbial infections, pains and inflammations. The powder leaf was extracted by<br/>maceration in 80% methanol for 24 hours and then fractionated using n-hexane, ethyl<br/>acetate and n-butanol. The crude extract and fractions were screened for the presence of<br/>saponins, tannins, flavonoids and triterpenoids/steroids. Total phenolic and flavonoid<br/>contents were determined using Folin–Ciocalteu’s reagent and aluminium chloride assays.<br/>The chemical profiling of ethyl acetate fraction, n-butanol and the crude extract were<br/>conducted by LC- MS/ LC-QTOF-MS based metabolomic profile analyses. The essential<br/>oil was analysed by GC-MS and revealed the presence of monoterpenoids,<br/>sesquiterpenoids and other compounds. The antioxidant activity was determined using<br/>DPPH, hydrogen peroxide and β-carotene assays. Agar disk diffusion and micro broth<br/>dilution methods were used for the antibacterial activity of the crude extract on<br/>Pseudomonas aeruginosa and Legionella pneumophila. Gentamicin (10 μg) was used as a<br/>positive control. The acute toxicity was determined using Lorke’s method. The analgesic<br/>activity assayed using acetic acid-induced writhing, hotplate and formalin-induced<br/>nociception. Anti-inflammatory activity was investigated by means of formalin-induced<br/>acute inflammation. The antipyretic activity was studied using Brewer’s yeast. The crude<br/>extract (CrESs)/fractions demonstrated antioxidant activity in all the models. The nhexane<br/>fraction (HFSs) had the highest scavenging activity with IC50 of 2.944 m/mL in<br/>the DPPH assay. In the H2O2 scavenging assay, the ethyl acetate fraction (EtFSs) had the<br/>highest scavenging activity (IC50 of 0.4352 mg/mL) and in the β-carotene bleaching assay<br/>with IC50 of 0.00014 mg/mL. Generally, the EtFSs had higher antioxidant activity when<br/>compared with other test samples and with ascorbic acid (2.944 mg/mL-Hexane, 9.29<br/>mg/mL-hydrogen peroxide and 2.85 mg/mL-β-carotene). The MIC of CrESs on<br/>Pseudomonas aeruginosa and Legionella pneumophila were 0.15625±0.00 mg/mL and<br/>0.3125±0.00 mg/mL respectively. The LD50 of the CrESs /fractions were greater than<br/>5000 mg/Kg. The CrESs/fractions demonstrated analgesic activity but it was higher in<br/>EtFSs when compared to piroxicam. The EtFSs showed higher anti-inflammatory activity<br/>than piroxicam at the late hours. The antipyretic study revealed at 200 mg/Kg, EtFSs<br/>fraction significantly reduced the rectal temperature of rats similar to paracetamol. The<br/>findings of this research have validated the uses of Scutellaria sibthorpii in traditional<br/>medicine as antibacterial, antioxidant, analgesic, anti-inflammatory and antipyretic. |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ | |
| Konusal terim veya coğrafi ad | Pharmaceutıcal Sciences |
| Alt başlık biçimi | Dissertations, Academic |
| 700 1# - EK GİRİŞ - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Halilu, Emmanuel Mshelia |
| İlişkili Terim | supervisor |
| 942 ## - EK GİRİŞ ÖGELERİ (KOHA) | |
| Sınıflama Kaynağı | Dewey Onlu Sınıflama Sistemi |
| Materyal Türü | Thesis |
| Geri Çekilme Durumu | Kayıp Durumu | Sınıflandırma Kaynağı | Kredi için değil | Koleksiyon Kodu | Kalıcı Konum | Mevcut Konum | Raf Yeri | Kayıt Tarih | Source of acquisition | Toplam Ödünçverme | Yer Numarası | Demirbaş Numarası | Son Görülme Tarihi | Kopya Bilgisi | Fatura Tarihi | Materyal Türü | Genel / Bağış Notu |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Depo | 27.09.2024 | Bağış | D 433 K67 2024 | T3892 | 27.09.2024 | C.1 | 27.09.2024 | Thesis | Pharmaceutıcal Sciences | ||||
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Görsel İşitsel | 27.09.2024 | Bağış | D 433 K67 2024 | CDT3892 | 27.09.2024 | C.1 | 27.09.2024 | Suppl. CD | Pharmaceutıcal Sciences |