SYNTHESIS AND BIOACTIVITY OF [4-(4-FLUORO-PHENYL)-PIPERAZIN-1YL]-(4-PHENYL-PIPERAZIN-1-YL)METHANE / (Kayıt no. 292985)
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| 000 -BAŞLIK | |
|---|---|
| Sabit Uzunluktaki Kontrol Alanı | 02716nam a22002657a 4500 |
| 003 - KONTROL NUMARASI KİMLİĞİ | |
| Kontrol Alanı | KOHA |
| 005 - EN SON İŞLEM TARİHİ ve ZAMANI | |
| Kontrol Alanı | 20250108102030.0 |
| 008 - SABİT UZUNLUKTAKİ VERİ ÖGELERİ - GENEL BİLGİ | |
| Sabit Alan | 240927d2024 cy deo|| |||| 00| 0 eng d |
| 040 ## - KATALOGLAMA KAYNAĞI | |
| Özgün Kataloglama Kurumu | CY-NiCIU |
| Kataloglama Dili | eng |
| Çeviri Kurumu | CY-NiCIU |
| Açıklama Kuralları | rda |
| 041 ## - DİL KODU | |
| Metin ya da ses kaydının dil kodu | eng |
| 090 ## - Yerel Tasnif No | |
| tasnif no | YL 3480 |
| Cutter no | R35 2024 |
| 100 1# - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Raissi, Yassine |
| 245 10 - ESER ADI BİLDİRİMİ | |
| Başlık | SYNTHESIS AND BIOACTIVITY OF [4-(4-FLUORO-PHENYL)-PIPERAZIN-1YL]-(4-PHENYL-PIPERAZIN-1-YL)METHANE / |
| Sorumluluk Bildirimi | YASSINE REISSI ; SUPERVISOR, ASST. PROF. DR. BANU KEŞANLI |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024 |
| 300 ## - FİZİKSEL TANIMLAMA | |
| Sayfa, Cilt vb. | 62 sheets ; |
| Boyutları | 30 cm |
| Birlikteki Materyal | +1 CD ROM |
| 336 ## - CONTENT TYPE | |
| Source | rdacontent |
| Content type term | text |
| Content type code | txt |
| 337 ## - MEDIA TYPE | |
| Source | rdamedia |
| Media type term | unmediated |
| Media type code | n |
| 338 ## - CARRIER TYPE | |
| Source | rdacarrier |
| Carrier type term | volume |
| Carrier type code | nc |
| 502 ## - TEZ NOTU | |
| Tez Notu | Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Chemistry |
| 520 ## - ÖZET NOTU | |
| Özet notu | Piperazine derivatives, with their wide range of biological activities, are among the most significant pharmacophores in medicinal chemistry. By strategically altering the structure and placing substitutuents at different positions of the piperazine core structure, these biological functions can be controlled. As a result, piperazine derivatives have been attractive building blocks for chemical synthesis and drug design.<br/>In this study, a novel piperazine derivative was synthesized via the Mannich process under reflux reaction, wherein the N-substituted phenylpiperazine ring was reacted with 4-fluorophenyl-piperazine, to give [4-(4-Fluoro-phenyl)-piperazin-1-yl] -(4-phenyl-piperazin-1-yl)-methane. The structure mainy consists of two piperazine rings bridged by a methylene group with fluorine atom as a substituent.<br/>Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR) and Fourier Transform Infra-Red (FT-IR) validated that compound was successful synthesized. In the FT-IR spectrum, the absence of an N-H stretches suggested that the reaction occurred at position one on N-atom. Melting point analysis and Thin Layer Chromatography (TLC) were used to assess the compound’s purity. In order to understand the pysiochemical and ADME (absorption, distribution, metabolism, and excretion) properties of the synthesized molecule for drug likeness studies computationally prediction was performed by using SwissADME online software software. Additionally, in terms of antimicrobial susceptibility, the disk diffusion test showed high to moderate efficiency against gram-positive (Bacillus) and gram-negative (E. coli) organisims after 24h incubation time. These findings point that this novel compound could have potential to be further studied as a drug candidate. |
| 650 #0 - KONU BAŞLIĞI EK GİRİŞ - KONU TERİMİ | |
| Konusal terim veya coğrafi ad | Chemistry |
| Alt başlık biçimi | Dissertations, Academic |
| 700 1# - EK GİRİŞ - KİŞİ ADI | |
| Yazar Adı (Kişi adı) | Keşanlı, Banu |
| İlişkili Terim | supervısor |
| 942 ## - EK GİRİŞ ÖGELERİ (KOHA) | |
| Sınıflama Kaynağı | Dewey Onlu Sınıflama Sistemi |
| Materyal Türü | Thesis |
| Geri Çekilme Durumu | Kayıp Durumu | Sınıflandırma Kaynağı | Kredi için değil | Koleksiyon Kodu | Kalıcı Konum | Mevcut Konum | Raf Yeri | Kayıt Tarih | Source of acquisition | Toplam Ödünçverme | Yer Numarası | Demirbaş Numarası | Son Görülme Tarihi | Kopya Bilgisi | Fatura Tarihi | Materyal Türü | Genel / Bağış Notu |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Depo | 23.10.2024 | Bağış | YL 3480 R35 2024 | T3927 | 23.10.2024 | C.1 | 23.10.2024 | Thesis | Chemistry | ||||
| Dewey Onlu Sınıflama Sistemi | Tez Koleksiyonu | CIU LIBRARY | CIU LIBRARY | Görsel İşitsel | 23.10.2024 | Bağış | YL 3480 R35 2024 | CDT3927 | 23.10.2024 | C.1 | 23.10.2024 | Suppl. CD | Chemistry |