ALKALOIDS, ANTIMICRIBIAL, AND ANTIOXIDANT ACTIVITIES OF PAPAVER UMBONAUM BOISS GROWING IN CYPRUS / ALAA ADEL ALKARAM; SUPERVISOR: Prof. Dr. ZEHRA GÜNAY SARIYAR

Yazar: Katkıda bulunan(lar):Dil: İngilizce 2022Tanım: 64 sheets; 31 cm. Includes CDİçerik türü:
  • text
Ortam türü:
  • unmediated
Taşıyıcı türü:
  • volume
Konu(lar): Tez notu: Thesis (MSc) - Cyprus International Univesity. Institute of Graduate Studies and Research Pharmacognosy Department Özet: ABSTRACT In this work the alkaloids of Papaver umbonatum Boiss. collected from Irbid, Jordan, have been studied. Bioactivity tests have also been performed to show antimicrobial, anti-biofilm, and antioxidant effects of tertiary alkaloid extracts and isolated alkaloids obtained from the species. Isopavine type amurensinine and promorphinane type flavinantine have been isolated from P. umbonatum Boiss. as the major alkaloids while another promorphine type alkaloid O-methylflavinantine was obtained as a minor one. This is the first report of isolation of the alkaloids from P. umbonatum. Presence of flavinantine as a major alkaloid has previously been shown in P. nudicaule. P. umbonatum Boiss. has been found a second Papaver species which contained this alkaloid. Isolation of O-methylflavinantine has been reported from genus Papaver for the first time. The structures of the alkaloids were identified by spectroscopic methods ( 1H-NMR, IR and UV spectrums) and by comparing their Thin Layer Chromatography (TLC) Rf values with those of authentic samples. Antimicrobial activity tests have been performed on Gram-negative Salmonella, Gram-positive methicillin resistant Staphylococcus aureus (MRSA), and gram-positive Bacillus subtilis bacteria. In this study Antioxidant activity was performed by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method for tertiary alkaloids extract of aerial parts of P. umbonatum Boiss. which showed that tertiary alkaloids extract of this plant on higher concentration possess better antioxidant potential when compare to reference standard citric acid. Keywords: Alkaloids, Antimicrobial Activity, Antioxidant Activity, Anti-biofilm Activity, Papaver umbonatum Boiss, Genus Papaver
Materyal türü: Thesis
Mevcut
Materyal türü Geçerli Kütüphane Koleksiyon Yer Numarası Durum Notlar İade tarihi Barkod Materyal Ayırtmaları
Thesis Thesis CIU LIBRARY Tez Koleksiyonu Tez Koleksiyonu YL 2720 A55 2022 (Rafa gözat(Aşağıda açılır)) Kullanılabilir Pharmacognosy Department T3049
Suppl. CD Suppl. CD CIU LIBRARY Görsel İşitsel YL 2720 A55 2022 (Rafa gözat(Aşağıda açılır)) Kullanılabilir Pharmacognosy Department CDT3049
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Thesis (MSc) - Cyprus International Univesity. Institute of Graduate Studies and Research Pharmacognosy Department

Includes bibliography (sheets 56-60)

ABSTRACT
In this work the alkaloids of Papaver umbonatum Boiss. collected from Irbid, Jordan,
have been studied. Bioactivity tests have also been performed to show antimicrobial,
anti-biofilm, and antioxidant effects of tertiary alkaloid extracts and isolated alkaloids
obtained from the species. Isopavine type amurensinine and promorphinane type
flavinantine have been isolated from P. umbonatum Boiss. as the major alkaloids while
another promorphine type alkaloid O-methylflavinantine was obtained as a minor one.
This is the first report of isolation of the alkaloids from P. umbonatum. Presence of
flavinantine as a major alkaloid has previously been shown in P. nudicaule. P.
umbonatum Boiss. has been found a second Papaver species which contained this
alkaloid. Isolation of O-methylflavinantine has been reported from genus Papaver for
the first time. The structures of the alkaloids were identified by spectroscopic methods
(
1H-NMR, IR and UV spectrums) and by comparing their Thin Layer Chromatography
(TLC) Rf values with those of authentic samples. Antimicrobial activity tests have
been performed on Gram-negative Salmonella, Gram-positive methicillin resistant
Staphylococcus aureus (MRSA), and gram-positive Bacillus subtilis bacteria. In this
study Antioxidant activity was performed by DPPH (2,2-diphenyl-1-picrylhydrazyl)
radical scavenging method for tertiary alkaloids extract of aerial parts of P.
umbonatum Boiss. which showed that tertiary alkaloids extract of this plant on higher
concentration possess better antioxidant potential when compare to reference standard
citric acid.
Keywords: Alkaloids, Antimicrobial Activity, Antioxidant Activity, Anti-biofilm
Activity, Papaver umbonatum Boiss, Genus Papaver

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