INVESTIGATION OF MALAT-1 LNCRNA LEVELS IN BREAST CANCER WITH GENOTOXIC STRESS / TEMITAYO JOHNSON FAGBOHUN; SUPERVISOR: ASSOC. PROF. DR. MUSTAFA IŞIN

Yazar: Katkıda bulunan(lar):Dil: İngilizce 2023Tanım: x, 54 sheets; 31 cm. Includes CDİçerik türü:
  • text
Ortam türü:
  • unmediated
Taşıyıcı türü:
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Konu(lar): Tez notu: Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Deparment Özet: ABSTRACT Breast cancer is the most common type of cancer in women globally, accounting for more than 30% of all new cancer diagnoses. Breast cancer accounts for more than 6% of all cancer-related fatalities, making it the most common female malignancy and the leading cause of mortality for women worldwide. Breast cancer has become a menace to the society that needs to be curbed. Accumulating evidence supports that aberrant regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. In our study, cytarabine was employed to induce genotoxic stress in MCF7 breast cancer cell lines. Besides, expression levels of lncRNA-MALAT1 was investigated. Our findings have shown that cytotoxic agent cytarabine prevented proliferation of MCF7 breast cancer cell lines leading to cell death and we observed lethality after 72hours of time interval. The expression levels of MALAT1 increased steadily till 72h of incubation with cytotoxic agent. This finding implicating that the exposure to cytotoxic agent increased the expression of MALAT1 pointing out to a relation of MALAT1 lncRNA and cell death. Keywords: Breast cancer, LncRNA, MALAT1, MCF
Materyal türü: Thesis
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Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Deparment

Includes bibliography (sheets 43-54)

ABSTRACT
Breast cancer is the most common type of cancer in women globally, accounting for
more than 30% of all new cancer diagnoses. Breast cancer accounts for more than 6%
of all cancer-related fatalities, making it the most common female malignancy and the
leading cause of mortality for women worldwide. Breast cancer has become a menace
to the society that needs to be curbed. Accumulating evidence supports that aberrant
regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a
long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. In our study,
cytarabine was employed to induce genotoxic stress in MCF7 breast cancer cell lines.
Besides, expression levels of lncRNA-MALAT1 was investigated. Our findings have
shown that cytotoxic agent cytarabine prevented proliferation of MCF7 breast cancer
cell lines leading to cell death and we observed lethality after 72hours of time interval.
The expression levels of MALAT1 increased steadily till 72h of incubation with
cytotoxic agent. This finding implicating that the exposure to cytotoxic agent increased
the expression of MALAT1 pointing out to a relation of MALAT1 lncRNA and cell
death.
Keywords: Breast cancer, LncRNA, MALAT1, MCF

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