SYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON 1-(4-PYRIMIDIN-2-YL-PIPERAZIN-1-YLMETHYL)- 1-BENZIMIDAZOLE / OKEKEYE OLUSHOLA PETER; SUPERVISOR: ASSIST. PROF. DR. BANU KEŞANLI
Dil: İngilizce 2023Tanım: x, 61 sheets; 31 cm. 1 CD-ROMİçerik türü:- text
- unmediated
- volume
Thesis
| Materyal türü | Geçerli Kütüphane | Koleksiyon | Yer Numarası | Durum | Notlar | İade tarihi | Barkod | Materyal Ayırtmaları | |
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Thesis
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CIU LIBRARY Tez Koleksiyonu | Tez Koleksiyonu | YL 3145 P48 2023 (Rafa gözat(Aşağıda açılır)) | Kullanılabilir | Chemistry Department | T3526 | |||
Suppl. CD
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CIU LIBRARY Görsel İşitsel | YL 3145 P48 2023 (Rafa gözat(Aşağıda açılır)) | Kullanılabilir | Chemistry Department | CDT3526 |
Thesis (MSc) -Cyprus International University. Institute of Graduate Studies and Research Chemistry Department
Includes bibliography (sheets 54-61)
ABSTRACT
Benzimidazole and their derivatives represent a class of chemical compounds that play
a vital role in medicinal chemistry. These compounds possess unique structural
attributes, affording them a wide spectrum of significant biological activities. The
biological activity of benzimidazole derivatives can be fine-tuned by changing the
location and type of the substituents. Consequently, they have become the subject of
extensive investigation and application in the field of drug development and discovery.
In this study, a novel Mannich base incorporating a pyrimidine piperazine derivative
was synthesized in a fast manner and with notable efficiency, utilizing benzimidazole
as the central structural motif. The benzimidazole core structure offers a great
advantage in terms of substituent substitution, allowing for the creation of compounds
with diverse biological activities. By varying the position and type of substituents on
the benzimidazole molecule, the resulting derivatives can be modified to effect specific
changes in biological activities. This flexibility in substitution provides a powerful tool
to explore and optimize the potential biological effects of benzimidazole compounds.
It opens up possibilities for designing molecules with enhanced therapeutic properties
and targeted interactions with biological systems. The ability to conveniently modulate
the activities of benzimidazole derivatives through structural modifications makes
them valuable candidates for organic synthesis and drug design.
The resulting compound underwent comprehensive characterization by melting point,
Thin Layer Chromatography, 1H-NMR and FT-IR spectroscopy. The preliminary antimicrobial efficacy of the newly synthesized Mannich base was evaluated utilizing the
disk diffusion method against E. coli and S. aureus.
Keywords: Antimicrobial Activity, Benzimidazole, Heterocycles, Mannich Base,
Piperazine.