FORMULATION OF ACETYLSALICYLIC ACID NANOPARTICLES USING SOLVENT EVAPORATION METHOD AND IN VIVO EVALUATION OF ITS ANTITHROMBOTIC EFFECT / LARA ALHAJI ; SUPERVISOR, ASST. PROF. DR. AIREMWEN COLLINS OVENSERİ

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Konu(lar): Tez notu: Thesis (PhD) - Cyprus International University. Institute of Graduate Studies and Research Pharmaceutıcal Sciences Özet: Nanotechnology offers several advantages in the treatment of chronic diseases through site-specific and target-oriented drug delivery. The purpose of this study was to formulate acetylsalicylic acid nanoparticles using the solvent evaporation method and evaluate the physicochemical properties of nanoparticles using X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and zeta sizer. In vitro dissolution studies, release kinetics, antioxidant and in vivo antithrombotic studies were also done. The formulated acetylsalicylic acid nanoparticles had a smooth and spherical shape with particle size of 76.25-128.17 nm, polydispersity index of 0.34-0.46 and encapsulation efficiency of 36.29-42.52%. The nanoparticles were positively charged and had a zeta potential value of ≤ +47.64 mV. The in vitro release studies showed that the acetylsalicylic acid nanoparticles released the drug in a sustained release manner simulating the Higuchi release model via non-Fickian diffusion mechanism. The formulated acetylsalicylic acid nanoparticles also showed significant antioxidant and antithrombotic effects in experimental rats (P<0.05). Acetylsalicylic acid nanoparticles were formulated in this study which may offer better therapeutic advantages over the convention acetylsalicylic acid tablets in the prevention and management of acute myocardial infarction and ischaemic stroke.
Materyal türü: Thesis
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Materyal türü Geçerli Kütüphane Koleksiyon Yer Numarası Kopya numarası Durum Notlar İade tarihi Barkod Materyal Ayırtmaları
Thesis Thesis CIU LIBRARY Depo Tez Koleksiyonu D 434 A44 2024 (Rafa gözat(Aşağıda açılır)) C.1 Kullanılabilir Pharmaceutıcal Sciences T3893
Suppl. CD Suppl. CD CIU LIBRARY Görsel İşitsel Tez Koleksiyonu D 434 A44 2024 (Rafa gözat(Aşağıda açılır)) C.1 Kullanılabilir Pharmaceutıcal Sciences CDT3893
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Thesis (PhD) - Cyprus International University. Institute of Graduate Studies and Research Pharmaceutıcal Sciences

Nanotechnology offers several advantages in the treatment of chronic diseases through
site-specific and target-oriented drug delivery. The purpose of this study was to
formulate acetylsalicylic acid nanoparticles using the solvent evaporation method and
evaluate the physicochemical properties of nanoparticles using X-ray diffraction
(XRD), scanning electron microscope (SEM), Fourier Transform Infrared
Spectroscopy (FTIR) and zeta sizer. In vitro dissolution studies, release kinetics,
antioxidant and in vivo antithrombotic studies were also done. The formulated
acetylsalicylic acid nanoparticles had a smooth and spherical shape with particle size
of 76.25-128.17 nm, polydispersity index of 0.34-0.46 and encapsulation efficiency of
36.29-42.52%. The nanoparticles were positively charged and had a zeta potential
value of ≤ +47.64 mV. The in vitro release studies showed that the acetylsalicylic acid
nanoparticles released the drug in a sustained release manner simulating the Higuchi
release model via non-Fickian diffusion mechanism. The formulated acetylsalicylic
acid nanoparticles also showed significant antioxidant and antithrombotic effects in
experimental rats (P<0.05). Acetylsalicylic acid nanoparticles were formulated in this
study which may offer better therapeutic advantages over the convention
acetylsalicylic acid tablets in the prevention and management of acute myocardial
infarction and ischaemic stroke.

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