Includes index. (447-462 p.)

Philip Hendry. Trevor J. Lockett, and Maxine J. McCall 1 Small Efficient Hammerhead Ribozymes

Arnold Hampel 17 The Hairpin Ribozyme: Discovery and Development for Gene Therapy

N.Kyle Tanner 29 Molecular Manipulations of the Catalytic RNAs From the Human Hepatitis

Lun-Quab Sun, Wayne Gerlach. and Geoff Symonds 51 The Design, Production , and Validation of an Anti-HIV Type 1 Ribozyme

Eric M. Poeschia, Mang Yu, Mark C. Leavitt. and Flossie Wong-Staal/ 65 Methods For Treating HIV by Gene Therapy Using Ribozymes

Jun Ohkawa, Yutaka Takebe, and Kazunari Taira 83 An Expression Vector for Multiple Ribozymes

Gerd Hobom and Annette Menke 97 Viral RNA Targets for Ribozymes : Influenza A virus

Fritz von Welzsacker, Hubert E.Blum, and Jack R. Wands 111 Hammerhead Ribozyme-Mediated Cleavage of Hepatitis B Virus RNA

Glenn H. Cantor 119 Bovine Leukemia Virus Ribozymes

David Y. Bouffard 131 Use of Ribozymes to Specifically Alter the MDR-1 Phenotype

Akira Irie, Jerry Tsai, and Mohammed Kashani -Sabet 153 Adenoviral-Mediated Anti-H-ras Ribozyme for the Treatment of Bladder Cancer

Tsukasa Ohkawa and Mohammed Kashani-Sabet 169 Tissue-Specific Delivery of an Anti-H-ras Ribozyme Against Malignant Melanoma

Hiroshi Kijima, David Y. Bouffard, and Kevin J. Scanlon 193 Ribozymes as a Novel Approach for the Treatment of Human Pancreatic Carcinoma

Alex W. Tong, Yu-An Zhang, John Nemunaitis and Gabriele Mues 209 K-ras Ribozyme for Lung Cancer

Toshiya Suzuki,Lisa D. Curclo, Jerry Tsai, and Mohammed Kashani-Sabet 223 Anti-C-erb-B-2 Ribozyme for Breast Cancer

Gunhild M Maelandsmo, Inge Kjonniksen, Elvind Hovig, Kevin J.Scanlon, and Oystein Fodstad 241 Ribozymes: Applications in Cancer Metastasis Research

Mouldy Sloud 261 Preformed Ribozymes: Strategies for Design and In Vivo Application as Anticytokine Agents

Lance H.Leopold, Scott K. Shore, Ramana M.V. Reddy and E. Premkumar Reddy 279 Folate-Polysine-Mediated Delivery of a Multiunit Anti-BAR/ABL Ribozyme to BCR/ABL-Transformed 32D Cells

Hiromichi Matsushita, Hiroyuki Kobayashi, Masahiro Kizaki, and Yasuo Ikeda 293 Ribozymes Targeted Against AML1/MTG8: Evaluation of Ribozyme Efficiency in a cell-Free System and Transfection with Cationic Lipsome

Frank Czubayka, Anke M.Schulte, and Anton Wellstein 311 Ribozyme Targeting of the Growth Factor Pleiotrophin

Thale C. Javis, Dennis Macejak, and Larry Couture 329 Ribozyme-Mediated Inhibition of Cell Proliferation : A Model for Identifying and Refining a Therapeutic Ribozyme

Mariyn Smedman and Robert B.Denman 341 Inhibition of βAPP Synthesis by Ribozymes and Oligonucleotides in a Coupled Reticulocyte Transcription Transcription Translation System

Joohun Ha 357 Selective Modification of Fatty Acid Synthesis Pathway by Expression of an Acetyl-CoA Carboxylase-Specific Ribozyme Gene

S. Petter Lyngstadaas, Brian S Sproat, Martina Biaschke Janos Ludwig, Thomas Rupp, and Hans P. Prydz 371 In Vivo Knockout of a Tissue-Specific Gene by Synthetic Ribozymes

Shimon Efrat 387 Ribozyme-Mediated Downregulation of Gene Expression in Transgenic Mice

Yan Yuan and Fenyong Liu 397 Targeted Cleavage of RNA Using External Guide Sequences and Eukaryotic RNase P

Yan Yuan 415 Application of In Vitro Selection in Design of External Guide Sequences That Direct Efficient Cleavage of RNA by RNase P

Katalin Kariko and Elliot S. Barnathan 427 A PCR-Based Approach to Hammerhead Ribozyme Synthesis

P. Kamath and E.J.Shillitoe 439 Measurement of Ribozyme Activity Using RNase Protection

447 Index