TY  - BOOK
AU  - HUSSAINI,Abubakar Ahmed
AU  - Supervisor: ÖZGÖR,Erkay
TI  - ANTICANCER EFFECT OF ETHANOLIC EXTRACT OF SOURSOP LEAVES AND SEEDS ON (MCF-7/MDA-MB-231) BREAST CANCER CELL LINES AND PROGESTERONE AND ESTROGEN RECEPTORS
KW  - Annona muricata
KW  - Escherichia coli
KW  - Pseudomonas aeruginosa
KW  - Bacillus subtilis
KW  - MDA-MB-231 cell lines
N1  - Includes CD; Thesis (MSc.) - CYPRUS INTERNATIONAL UNIVERSITY INSTITUTE OF GRADUATE STUDIES AND RESEARCH Bioengineering Department; Includes REFERENCES: sheets 63-68
N2  - ABSTRACT
The aim of this research is to evaluate the phytochemicals screening from ethanol extract of annona muricata leave and seeds tested for in vitro cytotoxic activity against MCF-7/MDA-MB-231 cell lines progesterone and estrogen receptors and bacteria to provide the potent activity from plant. Studies of phytochemical which involved extraction using ethanol solvents. The phytochemicals screening such as test of secondary metabolites that the sample contained. The leave and seeds extract was assayed for cytotoxicity against MCF-7/MDA-MB-231 cell lines progesterone and estrogen receptors by using MTT assay. The studies of Phytochemicals results showed that the ethanolic extract of annona muricata leave and seeds contain saponins flavonoids and tannins. The activity of cytotoxic effect against MFC-7/MDA-MB-231 cell lines and progesterone and estrogen receptors showed the CD50 value less than 1μg/ml, that present as a very good activity.
Keywords: Annona muricata, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, MDA-MB-231 cell lines
ER  -