TY  - BOOK
AU  - Owolabi,Olakunle Simeon
AU  - Işın,Mustafa
TI  - INVESTIGATION OF H19 LNCRNA LEVELS IN BREAST CANCER WITH GENOTIC STRESS
PY  - 2023///
KW  - Breast
KW  - Dissertations, Academic
KW  - Cancer
N1  - Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Department; Includes bibliography (sheets 40-54)
N2  - ABSTRACT
Breast Cancer without doubt is one of the leading health diseases in the world mostly 
in women. With the discovery of long non coding RNA (lncRNAs), our knowledge in 
the metastasis and progression of breast cancer has been doubling with each research 
carried out. The oncogene H19 lncRNA has been discovered to directly or indirectly 
influence cell proliferation, apoptosis, angiogenesis, inflammation and cell death 
among other processes. H19 levels regulation either upward or downward, has been 
suggested to cause cancer cell migration, metastasis and drug resistance. This research 
investigates H19 lncRNA levels in breast cancer cell after inducing genotoxic stress 
with the drug, Cytarabine. Our findings have shown that cytotoxic agent cytarabine 
stopped the proliferation of MCF-7 breast cancer cell lines and caused lethality after 
72 hours of time interval. The expression levels of H19 increased until 48 hours and 
decreased sharply at 72 hours implicating a relation between cytotoxic activity of 
cytarabine and the expression of H19.
Keywords: Breast Cancer, Cytarabine, H19, lncRNA
ER  -