TY  - BOOK
AU  - Fagbohun,Temitayo Johnson
AU  - Işın,Mustafa
TI  - INVESTIGATION OF MALAT-1 LNCRNA LEVELS IN BREAST CANCER WITH GENOTOXIC STRESS
PY  - 2023///
KW  - Breast
KW  - Dissertations, Academic
KW  - Cancer
N1  - Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Deparment; Includes bibliography (sheets 43-54)
N2  - ABSTRACT
Breast cancer is the most common type of cancer in women globally, accounting for 
more than 30% of all new cancer diagnoses. Breast cancer accounts for more than 6% 
of all cancer-related fatalities, making it the most common female malignancy and the 
leading cause of mortality for women worldwide. Breast cancer has become a menace 
to the society that needs to be curbed. Accumulating evidence supports that aberrant 
regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a 
long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. In our study,
cytarabine was employed to induce genotoxic stress in MCF7 breast cancer cell lines. 
Besides, expression levels of lncRNA-MALAT1 was investigated. Our findings have 
shown that cytotoxic agent cytarabine prevented proliferation of MCF7 breast cancer 
cell lines leading to cell death and we observed lethality after 72hours of time interval.
The expression levels of MALAT1 increased steadily till 72h of incubation with 
cytotoxic agent. This finding implicating that the exposure to cytotoxic agent increased 
the expression of MALAT1 pointing out to a relation of MALAT1 lncRNA and cell 
death.
Keywords: Breast cancer, LncRNA, MALAT1, MCF
ER  -