DNA SEQUENCE ANALYSIS BASED ON REPETITIVE PATTERNS /
BORIS NEBA AFUOHSAA; SUPERVISOR: PROF. DR. AHMET ADALIER
- viii, 65 sheets; 31 cm. Includes CD
Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Information Technologies Department
Includes bibliography (sheets 51-55)
ABSTRACT The volume of DNA data evolves worldwide in various Databanks. DNA data sets increase in size because they are increasingly being gathered. The difficulty of storing large DNA data brings about two major drawbacks which are the space needed to store these data sets and the time required to encode and decode them. In order to store and process DNA data in an effective way, encryption and compression algorithms are developed. The aim of this thesis is to implement a DNA sequence compression algorithm based on repetitive patterns. This compression technique not only reduces the number of characters of the DNA sequence but equally converts the DNA sequence into binary and thus reducing the storage space consumption of one character from 1-byte to a 2-bits binary. The experiments are conducted using DNA data from National Centre for Biotechnology Information (NCBI). The minimization of transmission time is attained in sending the DNA. The end results achieved an average compression ratio of 0.77, a compression of 1.8 bpb and with an average compression time of 3 seconds. The space saving average was obtained at a value of 77%. The disarrangement of DNA sequence of any living organism could therefore be easily determined with the use of this type of compression of DNA sequences. Keywords: Algorithm, Compression, DNA, Repetitive Patterns, Sequence.