GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING POMEGRANATE PEEL EXTRACT AND IT'S ANTIOXIDANT AND ANTICANCER ACTIVITIES AGAINST MDA-MB 231 BREAST CANCER CELL LINE /
ZINEB SARHAN ; SUPERVISOR, ASST. PROF. DR. PWADUBASHIYI COSTON PWAVODİ
- 66 sheets ; 30 cm +1 CD ROM
Thesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering
In this study, researchers explored the green synthesis of zinc oxide nanoparticles (ZnONPs) using pomegranate peel extract. The extract from Punica granatum fruit peels served as a crucial reducing and stabilizing agent during ZnONPs production. The synthesized samples were characterized using X-ray diffraction (XRD) and ultraviolet-visible (UV-vis) spectroscopy to determine their structural and optical properties. Additionally, Fourier Transform Infrared (FTIR) spectroscopy was employed to analyze the functional groups present in the synthesized nanoparticles. Notably, the ZnO NPs exhibited significant antioxidant activity against free radicals, demonstrating greater efficacy when synthesized with Punica granatum extract Furthermore, the ZnO NPs inhibited the growth of two bacterial strains, indicating their potential as antimicrobial agents. In vitro cytotoxicity studies revealed that ZnO NPs significantly affected the viability of breast cancer cells (MDA-MB 231), highlighting their potential application in cancer therapy. This comprehensive study underscores the multifaceted benefits of utilizing natural extracts for nanoparticle synthesis, researchers have demonstrated a sustainable approach to producing ZnO nanoparticles with promising biomedical and antimicrobial applications. Overall, this research opens new avenues for the development of eco-friendly and efficient nanomaterials for various scientific and medical applications. The study emphasizes the importance of natural resources in advancing nanotechnology and promotes further exploration of plant-based synthesis methods for future innovations.