Molecular Toxicology /
P. DAVID JOSEPHY, BENGT MANNERVIK
- Second Edition
- USA Oxford University Press 2006
- XVIII, 589 pages; 25.5 cm
Includes index
Includes references (pages 573-576)
Toxicity at the Cellular Level Toxicology of Oxygen 2 Covalent Binding of Xenobiotics to DNA and Protein 46 DNA Repair 83 Chemical Mutagenesis 122 Oncogenes, Tumor Suppressor Genes, and Mutations in Cancer Cells 155 Toxicity, Survival, and Target Theory 191 Enzymology of Biotransformation Cytochrome P450 Chemical and Biochemical Aspects 204 P450 Biological Aspects Regulation and Genetics 264 Biochemistry of Glutathione 303 Glutathione Transferases 333 Glutathione and Glutathione Transferases: Toxicological and Pharmacological Aspects 365 Glucuronic Acid Conjugation 402 Arylamine N-Acetyltransferase 426 Sulfotransferase 448 Molecular Principles Applied to Specifics Toxicants Alkylating Agents and "Mustards" 468 Oxidative Stress in the Erthrocyte Congenital and Xenobiotic-Induced Methemoglobinemia 484 Aromatic Amine and Related Toxic Compounds 509 Polycyclic Aromatic Hydrocarbon Carcinogens 531 Acetaminophen 562 Index