Includes index(1489-1519 p.)

MATERIAL SICENCE AND ENGINERING

PROPERTIES OF MATERIALS

Jack E. Lemons 5 Introduction: Properties of Materials: the Palette of the Biomaterials Engineering

Buddy D. Ratner 6 The Nature of Matter and Materials

Christopher Viney 9 Bulk Properties of Materials

Michael Sacks Antonio D'Amore. and Christopher Hobson 21 Finite Element Analysis in Biomechanics

Buddy D Ratner 34 Surface Properties and Surface Characterization of Biomaterials

Buddy D Ratner 55 Role of Water in Biomaterials

Classes of Materials Used in Medicine

Allan S Hoffman 63 Introduction: The Diversity and Versatility of Biomaterials

Daniel E Health and Stuart L Cooper 64 Polymers: Basic Principles

Daniel E Health and Stuart L Cooper 79 Polyurethanes

Andre Colas and Jım Curtıs 82 Sılıcones

Fang Lıu and David W Grainger 92 Fluorinated Biomaterials

Joe Antonucci and Sabine 103 Acrylics

John B Brunski 111 Metals: Basic Principles

Abhay Pandit Joesp Planeli and Meiba Navarro 120 Titanium and Nitinol (NiTi)

Phillip J Anderson 124 Stainless Steels

Larry L Hench and Serena M Best 128 Ceramics Glasses and Glass-Ceramics Basic Principles

Adele L Boskey 151 Natural and Synthetic Hydroxyapatites

Ketul C Popat and Tejal Desai 162 Alumina

Nicholas A Peppas and Allan S Hoffman 166 Hydrogel

Matthew Treiser. Sascha Abramson Robert Langer and Joachim Kohn 179 Degradable and Resorbable Biomaterials

Glenn D Prestwich and Sarah Atzet 195 Engineered Natural materials

Robert B More Axel D Haubold and Jack C Bokros 209 Pyrolytic Carbon for Long-Term Medical Implants

Claudio Migliaresi 223 Composites

Buddy D Ratner and Allan S Hoffman 241 Non-Fouling Surfaces

Alian S Hoffman 247 application of Smart Polymers as Biomaterials

Buddy D Ratner and Allan S Hoffman 259 Physiochemical Surface Modification of Materials Used in Medicne

Ryan T Hill and Ashutosh Chikoti 276 Surface Patterning

Martin W King and Sangwon Chung 301 Medical Fibers and Materials

Heidi E Koschwanez and William M Reichert 321 Textured and Porous Materials

Robert Akins and John Rabolt 332 Electrospinning Fundamentals and Applications

Alian S Hoffman and Jeffrey A Hubbell 339 Surface -Immobilized Biomolecules

Drew Elizabeth Glaser and Christopher Viney 349 Biomimetic Materials

Shalu Suri Gang Ran Jessica Winter Christine E Schmidt 360 Microparticles and Nanoparticles

Some Background Concepts

Buddy D Ratner 393 Introduction: Biology and Medicine -Key Concepts In the Use of Biomaterials in Surgery and Medical Devices

Thomas A Horbett 394 Adsorbed Proteins on Biomaterials

S Adam Hacking and Ali Khademhosseini 408 Cells and Surface in Vitro

Richard N Mitchell and Fredrick J Mitchell 452 Tissues The Extracellular Matrix and Cell-Biomaterial Interactions

Daniel E Conway Suzanne G Eskin, and Larry V Mclntire 474 Effects of Mechanical Forces on Cells and Tissues ( The Liquid-Cell Interface)

Richard L. Carpernedo and Todd C. McDevitt 487 Stem Cells: Key Concepts

HOST REACTION TO BIOMATERIALS AND THEIR EVALUATION

Fredrick J Schoen 499 Introduction: Biological Responses to Biomaterials

James M Anderson 503 Inflammation, wound Healing and the Foreign-Body Response

Richard N Mitchell 512 Innate and Adaptive Immunity : The Immune Response to Foreign Materials

Richard J Johnson 533 The Complement System

Arne Hensten and Nils Jacobson 545 Systemic Toxicity and Hypersensitivity

Stephen R Herison and Erik Tucker 551 Blood Coagulation and Blood -Materials Interactions

Fredrick J Shoen 558 Tumors Associated with Biomaterials and Implants

Paul Stoodley, Launne Hali Stoodley Bill Costerton Patrick Demeo Mark Shirtiff Ellen Gawalt and Sandeep Kathju 565 Biofilms Biomaterials and Device Related Infections

Biological Testing of Biomaterials

How Well Will It Work? Introduction to Testing Biomaterials Buddy D Ratner 587

The Concept and Assessment of Biocompatibility Buddy D Ratner and Fredrick Shoen 588

In Vitro Assessment of Cell and Tissue Compatibility Michael F Wolf , Kelly P Coleman and Gregory M Lewerenz 593

In Vivo Assessment of Tissue Compatibility James M Anderson and Fredrick J Schoen 609

Evaluation of Blood Materials Interactions Buddy D Ratner and Thomas A Horbett 617

Animal Surgery and Care of Animals David Lee Parritz 635

Large Animal Models In Cardiac and Vascular Biomaterials Research and Assessment Richard W Bianco Karen R Wasiluk Jessica M Voight Matthew T lahti Andrew I Rivard and Robert P Gallegos 653

Microscopy for Biomaterials Science Kip P Hauch and Buddy D Ratner 677

Degradation of Materials in the Biological Environment

Introduction The Body Fights Backs Degradation of Materials in the Biological Environment Buddy D Ratner 695

Chemical and Biochemical Degradation of Polymers Intended to be Biostable Arthur J Coury 696

The Biodegradation of Biodegradable Polymeric Biomaterials Chien-Chi Lin and Kristi S Anseth 716

Degradative Effects of the Biological Environment on Metals and Ceramics David F Williams and Rachel L Willams 728

Pathological Calcification of Biomaterials Fredrick J Shoen and Robert J Levy 739

Application of Biomaterials

Introduction: Applications of Biomaterials Fredrick J Shoen and Jack E Lemons 757

Nonthrombogenic Materials and Strategies: Case Study Michael V Sefton 758

Introduction to Cardiovascular Medical Devices Fredrick J Shoen 760

Substitute Heart Valves Fredrick J Schoen and Robert F Padera jr 761

Endovascular Stents Vascular Grafts and Stent Grafts Fredrick J Schoen and Robert F Padera jr 771

Other Cardiovascular Device Robert F Padera Jr and Fredrick Schoen 784

Implantable Cardiac Assist Devices and IABPs Marc A Simon Harvey S Barovetz William R Wagner 799

Artificial Cells Thomas Ming Swi Chang 811

Extracorporeal Artificial Organs Alastair Campell Ritchie 827

Orthopedic Applications Nadim James Hallab and Joshua James Jacobs 841

Dental Implantation Jack E Lemons and Carl E Misch 882

Adhesives and Sealants David Christopher watts 889

Ophthalmologic Application Introduction Roger Steinert and Rakhi Jain 905

Biomaterials: Contact Lenses Jean Jacob 909

Intraocular Lens Implants: A Scientific Perspective Anil S Patel 817

Corneal Inlays and Onlays Crystal Cunanan 930

Ophthalmologic Applications: Glaucoma Brains and Implants Crystal Cunanan 940

The Development of a Retinal Prosthesis A Significant Biomaterials Challenge Mark S Humayun Adrian P Rowley John J Whalen III, James D Welland and Armand R Tanguay 946

Bioelectrodes Ramakrishan Venugopam and Ray Ideker 957

The Role of Biomaterials in Stimulating Bioelectrodes P Hunter Peckham D Michael Ackarmann Jr and Christa W Moss 981

Medical Biosensors Lisa Lafleur and Paul Yager 996

Burn Bressings and Skin Substitutes Douglas L 1006

Sutures M Scott Taylor and Shalaby W Shalaby 1010

Drug Delivery System Allan S Hoffman Editor 1024

Introduction Allan S Hoffman 1024

Injected Nanomaterials Allan S Hoffman wayne R Gombotz and Suzie H Pun Editors 1027

PEGylation of Drugs and Nanomaterials Allan S Hoffman and Suzie H pun 1028

Patrick S Stayton Bilal Ghasn and John T Wilson Targeting 1028

Suzie H Pun and Allan S Hoffman Polymer Drug Conjugate 1036

Wayne R Gombotz Liposomes 1039

Wayne R Gombotz and Allan Hoffman Polymeric Micelles 1041

Wayne R Gombotz Dendrimers 1045

Suzie H Pun and Allan S Hoffman Nucleic Acid Delivery 1047

Wayne R Gombotz Polymeric and Albuminated Drug Nanoparticles 1054

Wayne R Gombotz and Allan S Hoffman Injected Depot DDS, 1055

Lothar W Kleiner and Jeremy C Wright Implants and Insects 1062

Allan S Hoffman Smart DDS, 1071

Gary Cleary Transdermal DDS 1073

Clive G Wilson Oral Drug 1083

Gonzalo Domingo Kenneth R Hawkins Roger B Peck and Bernhard H Weigi Diagnostic Application of Biomaterials 1087

Jim Curtis and Andre Colas Medical Applications of Silicones 1106

Applications of Biomaterials in Functional Tissue Engineering

Fredrick Schoen Introduction: Rebuilding Humans Using Biology and Bimaterials 1119

Debarijan Sarkar Weian Zhao Sabatian Scharfer James A Arikrum Grace S L Teo Maria Nuries Pereira Lino Ferreira and Jeffrey M Karp Overview of Tissue Engineering Concepts and Applications 1122

Milind Singh F Kurtis Kasper and Antonios G mIkos Tissue Engineering Scaffolds 1138

Arnoid I Caplan Cell Sources for Tissue Engineering: Mesenchymal Stem Cells 1159

Kaustah Ghosh Charles K Thodeti and Donald E Ingber Micromechanical Design Criteria for Tissue Engineering Biomaterials 1165

Nina Tandon Elisa Cimetta, Sarindr Bhumiratana Amandine Godier Furnermont Robert Maidhof and Gordana Vunjak Novakovic Bioreactors for Tissue Engineering 1178

Justin L Brown Sangamesg G Kumbar and Cato Ceto T Laurencin Bone Tissue Engineering 1194

Catherine K Kuo Wan-ju Li and Rocky S Tuan Cartilage and Ligament Tissue Engineering: Biomaterial Cellular Interactions and Regenerative Strategies 1214

Stacy C Schutte and Robert M Nerem Blood Vessel Tissue Engineering 1237

Fredrick J Schoen and Simon P Hoerstrup Heart Valve Tissue Engineering 1246

Amandine Godier-Fumemont and Gordana Vunjak -Novakovic Cardiac Muscle Tissue Engineering 1262

J N Mansbridge Tissue-Engineered Skin Substitutes 1276

Buddy D Ratner Esophageal and Gastrointestinal Tissue Engineering 1288

Ravi V Bellamkonda Isaac P Clements and Jennifer M Murison Neuronal Tissue Engineering 2191

Roshni S Rainbow and Michael J Lysaght Immunoisolation 1306

Stephen F Badylak Bryan N Brown and Thomas W Gilbert Tissue Engineering With Decellularized Tissues 1316

Practical Aspects of Biomaterials

Implants Devices and Biomaterials Special Considerations

Fredrick J Schoen Introduction Implants Device and Biomaterials Special Considerations

Byron Lambert and Jeffrey Martin Sterilization of Implants and Devices 1339

Buddy D Ratner Correlation Materials Properties Statistics and Biomaterials Sciences 1354

Fredrıck J Schoen and Allan S Hoffman Devıce Faılure Mode Analysıs 1361

James M Anderson Fredrick J Schoen Stanley A Brown and Katherine Merit Implant Retrieval and Evaluation 1368

Voluntary Standards Regulatory Compliance and Non-Technical Issues

Frederick J Schoen and Jack E Lemons Introduction: Voluntary Standards Regulatory Compliance and Other Non-technical Issues 1387

Joshua Tolkoff and Richard Anders Commercialization: What it Takes to get a Product to Market 1389

Jack E Lemons Voluntary Overview For Medical Products Using Biomaterials 1399

Elaine Duncan Regulatory Overview for Medical Products Using Biomaterials 1405

Fred Cahn Principles of Reimbursement For Medical Product Device 1413

Gail D Baura Corporate Considerations On Biomaterials and Medical Devices: Case Studies in Regulation and Reimbursement 1418

Taufiek Rejab Andrew L Rivard Karen R Wasiluk Robert P Gallegos and Richard W Bianco Ethical Issues In Biomaterials and Materials Devices 1425

Jay P Mayesh and Angela R Vicari Legal Aspects Of Biomaterials 1431

Gary L Grurikemeier Ruyun Jin Lian Wang and Albert Starr Clinical Trials For Medical Devices 1443

Robert Langer Jason Fuller and Mark Levin Entrepreneurship in Biomaterials 1459

David W Feigal Jr Postmarket Consideration in Biomaterials and Medical Devices 1472

Appendices

Steven M Slack Properties of Biological Fluids 1479

M Cristina L Martins Properties of Soft Materials 1483

Jack E Lemons Chemical Compositions of Metals Used For Implants 1485

Buddy D Ratner The Biomaterials Literature 1486

Index 1489