000			02169nam a22002777a 4500
003			KOHA
005			20230418151635.0
008			230317d2023 cy ||||| m||| 00| 0 eng d
040			_aCY-NiCIU _beng _cCY-NiCIU _erda
041			_aeng
090			_aYL 2811 _bO96 2023
100	1		_aOwolabi, Olakunle Simeon
245	1	0	_aINVESTIGATION OF H19 LNCRNA LEVELS IN BREAST CANCER WITH GENOTIC STRESS / _cOLAKUNLE SIMEON OWOLABI; SUPERVISOR: ASSOC. PROF. DR. MUSTAFA IŞIN
264			_c2023
300			_axii, 54 sheets; _c31 cm. _eIncludes CD
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
502			_aThesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Department
504			_aIncludes bibliography (sheets 40-54)
520			_aABSTRACT Breast Cancer without doubt is one of the leading health diseases in the world mostly in women. With the discovery of long non coding RNA (lncRNAs), our knowledge in the metastasis and progression of breast cancer has been doubling with each research carried out. The oncogene H19 lncRNA has been discovered to directly or indirectly influence cell proliferation, apoptosis, angiogenesis, inflammation and cell death among other processes. H19 levels regulation either upward or downward, has been suggested to cause cancer cell migration, metastasis and drug resistance. This research investigates H19 lncRNA levels in breast cancer cell after inducing genotoxic stress with the drug, Cytarabine. Our findings have shown that cytotoxic agent cytarabine stopped the proliferation of MCF-7 breast cancer cell lines and caused lethality after 72 hours of time interval. The expression levels of H19 increased until 48 hours and decreased sharply at 72 hours implicating a relation between cytotoxic activity of cytarabine and the expression of H19. Keywords: Breast Cancer, Cytarabine, H19, lncRNA.
650		0	_aBreast _vDissertations, Academic _xCancer
700	1		_aIşın, Mustafa _esupervisor
942			_2ddc _cTS
999			_c289984 _d289984