000 02299nam a22002777a 4500
003 KOHA
005 20230417091214.0
008 230322d2023 cy ||||| |m|| 00| 0 eng d
040 _aCY-NiCIU
_beng
_cCY-NiCIU
_erda
041 _aeng
090 _aYL 2848
_bF24 2023
100 1 _aFagbohun, Temitayo Johnson
245 1 0 _aINVESTIGATION OF MALAT-1 LNCRNA LEVELS IN BREAST CANCER WITH GENOTOXIC STRESS /
_cTEMITAYO JOHNSON FAGBOHUN; SUPERVISOR: ASSOC. PROF. DR. MUSTAFA IŞIN
264 _c2023
300 _ax, 54 sheets;
_c31 cm.
_eIncludes CD
336 _2rdacontent
_atext
_btxt
337 _2rdamedia
_aunmediated
_bn
338 _2rdacarrier
_avolume
_bnc
502 _aThesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering Deparment
504 _aIncludes bibliography (sheets 43-54)
520 _aABSTRACT Breast cancer is the most common type of cancer in women globally, accounting for more than 30% of all new cancer diagnoses. Breast cancer accounts for more than 6% of all cancer-related fatalities, making it the most common female malignancy and the leading cause of mortality for women worldwide. Breast cancer has become a menace to the society that needs to be curbed. Accumulating evidence supports that aberrant regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. In our study, cytarabine was employed to induce genotoxic stress in MCF7 breast cancer cell lines. Besides, expression levels of lncRNA-MALAT1 was investigated. Our findings have shown that cytotoxic agent cytarabine prevented proliferation of MCF7 breast cancer cell lines leading to cell death and we observed lethality after 72hours of time interval. The expression levels of MALAT1 increased steadily till 72h of incubation with cytotoxic agent. This finding implicating that the exposure to cytotoxic agent increased the expression of MALAT1 pointing out to a relation of MALAT1 lncRNA and cell death. Keywords: Breast cancer, LncRNA, MALAT1, MCF
650 0 _aBreast
_vDissertations, Academic
_xCancer
700 1 _aIşın, Mustafa
_esupervisor
942 _2ddc
_cTS
999 _c290026
_d290026