000			03253nam a22003257a 4500
003			KOHA
005			20231030143520.0
008			231030d2023 cy ||||| |m|| 00| 0 eng d
040			_aCY-NiCIU _beng _cCY-NiCIU _erda
041			_aeng
090			_aYL 3145 _bP48 2023
100	1		_aPeter, Okekeye Olushola
245	1	0	_aSYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON 1-(4-PYRIMIDIN-2-YL-PIPERAZIN-1-YLMETHYL)- 1-BENZIMIDAZOLE / _cOKEKEYE OLUSHOLA PETER; SUPERVISOR: ASSIST. PROF. DR. BANU KEŞANLI
264			_c2023
300			_ax, 61 sheets; _c31 cm. _e1 CD-ROM
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
502			_aThesis (MSc) -Cyprus International University. Institute of Graduate Studies and Research Chemistry Department
504			_aIncludes bibliography (sheets 54-61)
520			_aABSTRACT Benzimidazole and their derivatives represent a class of chemical compounds that play a vital role in medicinal chemistry. These compounds possess unique structural attributes, affording them a wide spectrum of significant biological activities. The biological activity of benzimidazole derivatives can be fine-tuned by changing the location and type of the substituents. Consequently, they have become the subject of extensive investigation and application in the field of drug development and discovery. In this study, a novel Mannich base incorporating a pyrimidine piperazine derivative was synthesized in a fast manner and with notable efficiency, utilizing benzimidazole as the central structural motif. The benzimidazole core structure offers a great advantage in terms of substituent substitution, allowing for the creation of compounds with diverse biological activities. By varying the position and type of substituents on the benzimidazole molecule, the resulting derivatives can be modified to effect specific changes in biological activities. This flexibility in substitution provides a powerful tool to explore and optimize the potential biological effects of benzimidazole compounds. It opens up possibilities for designing molecules with enhanced therapeutic properties and targeted interactions with biological systems. The ability to conveniently modulate the activities of benzimidazole derivatives through structural modifications makes them valuable candidates for organic synthesis and drug design. The resulting compound underwent comprehensive characterization by melting point, Thin Layer Chromatography, 1H-NMR and FT-IR spectroscopy. The preliminary antimicrobial efficacy of the newly synthesized Mannich base was evaluated utilizing the disk diffusion method against E. coli and S. aureus. Keywords: Antimicrobial Activity, Benzimidazole, Heterocycles, Mannich Base, Piperazine.
650		0	_aAnti-infective agents _vDissertations, Academic
650		0	_aBenzimidazoles _vDissertations, Academic
650		0	_aHeterocyclic compounds _vDissertations, Academic
650		0	_aMannich bases _vDissertations, Academic
650		0	_aPiperazine _vDissertations, Academic
700	1		_aKeşanlı, Banu _esupervisor
942			_2ddc _cTS
999			_c291594 _d291594