000			02948nam a22002657a 4500
003			KOHA
005			20241009114232.0
008			240924d2024 cy df||| |||| 00| 0 eng d
040			_aCY-NiCIU _beng _cCY-NiCIU _erda
041			_aeng
090			_aYL 3410 _bO86 2024
100	1		_aOsoata, Omono Veronica
245	1	0	_aSYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON 3-METHYL-1-(4-PHENYL-PIPERAZINE-1-YLMETHYL)-1H-INDOLE / _cBY OMONO VERONICA OSOATA ; SUPERVISOR ASST.PROF.DR. BANU KEŞENLI
264			_c2024
300			_a58 sheets : _bgrafics, illustrations ; _c30 cm _e+ 1 CD-ROM
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
502			_aThesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Chemistry
520			_aA class of chemical compounds known as indole and its derivatives are one of the important pharmacophores in the field of medical chemistry. These compounds have distinct structural characteristics that enable them to engage in a variety of important biological activities. By varying the location and kind of substituent, indole derivatives' biological activity can be adjusted. As a result, they have been focus of in-depth research and use in the field of development and discovery of new drugs. The flexibility in substitution on indoles provides a powerful tool to explore and optimize the potential biological effects of these compounds. It opens up possibilities for designing molecules with enhanced therapeutic properties and targeted interactions with biological systems. The ability to conveniently modulate the activities of indole derivatives through structural modifications makes them valuable candidates for organic synthesis and drug design. In this work, an indole-piperazine derivative was prepared under reflux condition through Mannich reaction to yield a 3-methylindole substituted by phenylpiperazine ring on the N-atom of the indole ring. Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR) and Fourier Transform Infra-Red (FT-IR) were used to characterize the target molecule. The FT-IR spectra of the synthesized molecule, showed the absence of N-H stretch which indicated that the reaction has actually taken place at position 1. Also the Mass Spectrometry result (ESI-MS) was used to confirm the molecular weight of the synthesized molecule and its fragmentation. To examine the purity of the synthesized molecule, Thin Layer Chromatography (TLC) and melting point were conducted. Disk diffusion technique was also carried out for antimicrobial susceptibility studies. The disk diffusion technique showed low to moderate activity to gram positive (Bacillus) and gram negative ( E. coli) microorganism.
650		0	_aChemistry _vDissertations, Academic
700	1		_aKeşanlı, Banu _esupervisor
942			_2ddc _cTS
999			_c292832 _d292832