000			02739nam a22002657a 4500
003			KOHA
005			20241008085151.0
008			240924d2024 cy o|||| |||| 00| 0 eng d
040			_aCY-NiCIU _beng _cCY-NiCIU _erda
041			_aeng
090			_aYL 3416 _bB34 2024
100	1		_aBadar, Abdul Salam M B
245	1	0	_aPHARMACOGNOSTIC AND BIOLOGICAL STUDIES OF Thevetia peruviana (Pers.) K. / _cBY ABDUL SALAM M B BADAR ; SUPERVISOR ASST. PROF.DR. EMMANUEL MSHELIA HALILU
264			_c2024
300			_a45 sheets : _bphotos ; _c30 cm _e+ 1 CD-ROM
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
502			_aThesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Pharmacognosy
520			_aThevetia peruviana have been used for its cardiotonic, anticancer, anti-inflammatory and antidiabetic activities. The current study is aimed to evaluate the pharmacognostic and biological activities of Thevetia peruviana leaf extract. The study is further designed to evaluate some microscopic features, physicochemical, phytochemical, antioxidant and antibacterial activities of the leaf extract. The microscopic analysis was conducted with the aid of the microscope. The physicochemical analysis was done using standard methods. The phytochemical test for the tannins, alkaloids, flavonoids, and other metabolites were carried out using standard methods. The DPPH assay was used to evaluate the free radical scavenging activity. The antibacterial activity was carried out using the disk diffusion method. The microscopic study revealed the presence of paracytic stomata surrounded by subsidiary cells and multicellular glandular trichomes. The moisture content was 18.5%. The petroleum ether, alcohol and water-soluble extractive values were 20%, 25% and 25% respectively. The phytochemical screening revealed the presence of alkaloids, tannins, flavonoids and triterpenoids. The leaf extract of Thevetia peruviana showed antibacterial activity on Escherichia coli and Staphylococcus aureus with inhibition zones of 10.6 mm and 9.66 mm, respectively. The free radical scavenging activity demonstrated by the extract was expressed in terms of the IC50 where the extract had IC50 of 0.142 mg/mL and the ascorbic acid had IC50 of was 0.0296 mg/mL. The antibacterial and free radical scavenging activities demonstrated by the extract have validated the use of the plant for treatment of the claims of the use of the plant in traditional medicine.
650		0	_aPharmacology _vDissertations, Academic
700	1		_aHalilu, Emmanuel Mshelia _esupervisor
942			_2ddc _cTS
999			_c292838 _d292838