000			02997nam a22002657a 4500
003			KOHA
005			20250109100018.0
008			240927d2024 cy eo||| |||| 00| 0 eng d
040			_aCY-NiCIU _beng _cCY-NiCIU _erda
041			_aeng
090			_aYL 3469 _bS23 2024
100	1		_aSadıq, Zainab Jega
245	1	4	_aTHE POTENTIAL WOUND HEALING ACTIVITY OF CHITOSAN-GUM ARABIC COMPLEX LOADED WITH CHAMOMILE AND HONEY / _cZAINAB JEGA SADIQ ; SUPERVISOR, ASST. PROF. DR. ALI ZAHER KAMEL AL-KALEEL
264			_c2024
300			_a55 sheets ; _c30 cm _e+1 CD ROM
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
502			_aThesis (MSc) - Cyprus International University. Institute of Graduate Studies and Research Bioengineering
520			_aThe management of wounds creates a significant challenge in the healthcare sector. Any deviation in the natural healing process leads to impaired tissue regeneration, posing numerous problems. The use of chemical compounds to promote wound healing has been practiced for long time. However, the trajectory of modern medicine towards natural compounds necessitates finding new methods to enhance such compounds. The aim of this research is to synthesize a chitosan and gum Arabic polyelectrolyte complex loaded with chamomile and honey and explore its activities as a potential healing promoter. This study investigates the fabrication of a Chitosan -gum Arabic complex loaded with honey and chamomile as a potential wound healing promoter. Characterization analyses, including Zeta size, UV-Vis, and FTIR were carried out to determine the physicochemical properties of the complex. The antioxidant activity and cell migration activity of the synthesized nanoparticles were then analyzed to determine their potential as wound healing promoter. The synthesized nanoparticle exhibited the presence of alkyne, alkyl, hydroxyl, ester or ether and amines or amide groups similar to those in chitosan and gum Arabic, indicating their effective combination and formation of a complex. Phenol and alcohol groups were also present, likely attributed to the phenolic compounds in the honey and chamomile. The synthesized complex demonstrated enhanced radical scavenging activity compared to the herbal formulation and had a lower IC50 value than the extract and ascorbic acid, highlighting its increased efficacy at lower doses. There was also a significant increase in the rate of wound closure in the nanoparticles group compared to all other groups. The wound closure percentage increased with the concentration of nanoparticles. The synthesized Chitosan -gum Arabic complex has displayed favorable traits as a potential wound healing agent and warrants further to fully understand its chemical and biological properties.
650		0	_aBioengineering _vDissertations, Academic
700	1		_aAl-Kaleel, Ali Zaher Kamel _esupervısor
942			_2ddc _cTS
999			_c292959 _d292959